cannabidoil for pain relief

Cannabidiol for pain relief has sedative effects and helps increases alertness. Despite a very low affinity for CB1 and CB2 receptors, cannabidiol (CBD) antagonizes and acts on different types of receptors. It increases the concentration of synaptic anandamide by inhibition recapture by the hydrolysis of FAAH (fatty-acid amide hydrolase) enzyme.

It is a cannabinoid that is derived from cannabis. It comes as no surprise it has attracted widespread research. The cannabinoid is second only to THC and has a concentration of 0.1-2.9 percent. 

Cannabidiol (CBD) is one of the main components of the marijuana plant. Unlike THC (tetrahydrocannabinol, the other main component) it does not produce negative mental effects. While THC is responsible for psychotic effects, CBD decreases and controls them. It is anti-anxiety and reduces paranoia.

It calms pain and inhibits the neuronal transmission of pain, which makes it ideal for patients with fibromyalgia, chronic pain, multiple sclerosis, and cancer.

When it comes to reducing anxiety, it acts directly on the central nervous system contributing to the release of relaxing hormones. People with anxiety disorders, such as post-traumatic stress, obsessive-compulsive disorder or social anxiety can benefit immensely from CBD. In one experiment, a patient took CBD oil for 7 days and found immediate relief from her panic attacks.


It is present in three drugs: Sativex, Epidiolex, and Cannador. Cannabidiol modulates the effects of THC. It would also have psychoactive properties but further objective scientific studies are required to clarify these effects on brain function.

Other research also shows that CBD increases alertness. It may decrease the rate of THC elimination in the body by interfering with its metabolism in the liver. Cannabidiol is a very lipophilic product and is found in breast milk. It would also have an effect on nicotine receptors and play a role in stopping and quitting smoking.

Medically, it is used to treat convulsions, inflammation, anxiety, and nausea, as well as to inhibit the growth of cancer cells  Recent studies have shown that it is effective in the treatment of schizophrenia and it could relieve the symptoms of dystonia. Research is ongoing as a treatment for epilepsy.

Mechanism of action

It acts on other targets, including the receptors involved in pain or the serotoninergic system as a 5-HT1A receptor agonist and other opioid receptors. It acts through the desensitization of the ion channels and antagonizing the serotoninergic 5HT3A receptor. It has the capacity to potentiate the analgesic effect of THC.

Cannabidiol is a potent inhibitor of CYP2D6 and CYP2C19. Elimination is slow and essentially biliary. 

Presence of cannabidiol in industrial hemp - The industrial variety "Fedora 17" contains 1 percent cannabidiol on the total mass. Extraction can be done with olive oil, ethanol or CO2.

Unlike THC (tetrahydrocannabinol), CBD is not controlled by the narcotics regulation because it does not result in a comparable psychoactive effect. CBD cannabis can, therefore, be sold legally as long as it contains less than 1 percent THC. 

You can get CBD oil in a pure concentrated form, in capsules or in balsams and sprays for external applications. Remember that it is very powerful and should only be taken in small quantities. Studies are still underway to check its effectiveness, but the results are very promising. Without a doubt, it is one of the great medicinal secrets of nature.

Additional benefits

Applying the oil directly on the skin has a regenerating effect on the cells, delaying the oxidation process that produces wrinkles and spots. It has antitumor properties and prevents the migration, invasion, and adhesion of cancer cells. In a study published in the Journal of Pharmacology and Experimental Therapeutics, it was shown that CBD inhibited the growth of breast cancer tumors. 

It can be used as a parallel treatment because it reduces pain and calms anxiety, two things that greatly affect cancer patients. Cannabidiol for pain relief has the capacity to increases appetite and stimulates the digestive system. This could be very useful for people who are recovering from diseases, those who want to gain a little weight or those who have lost appetite due to conditions, such as depression.

It has antioxidant properties, which helps prevent degenerative cardiovascular diseases. On the other hand, it relaxes the blood vessels, which could help reduce blood pressure and improve circulation.